منابع مشابه
Mechanisms of oral tolerance revisited
Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding pro...
متن کاملOral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms
Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...
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Drought stress is one of the most limiting abiotic stresses affecting growth, production and survival of plants in many areas of the world, and is expected to intensify considering the trend of climate change. Grass species are important for the sustainability of agricultural systems, forage resources for animal farming and landscapes. Grass species adapt to water deficit by different morpholog...
متن کاملOral tolerance, an active immunologic process mediated by multiple mechanisms.
Oral tolerance, the specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen by the oral route, probably evolved to prevent hypersensitivity reactions to food proteins and bacterial antigens present in the mucosal flora. As with other forms of immunologic tolerance, oral tolerance also provides mechanisms to suppress pathologic reacti...
متن کاملDevelopment of Oral Tolerance
"Oral (food) tolerance" usually describes a clinical situation that is not necessarily synonymous with the immunological definition of "tolerance," that is, as observed during development, transplantation or neonatal tolerance. In the context of this chapter, "oral tolerance" is defined as an antigen-specific immunological hyporesponsiveness after prior enteral administration. Oral exposure to ...
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ژورنال
عنوان ژورنال: Pediatric Clinics of North America
سال: 2015
ISSN: 0031-3955
DOI: 10.1016/j.pcl.2015.07.013